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Keratinocytes

Wound healing - keratinocytes
Cultured epidermis grafts

Detailed information are discussed in the following text. Please see also our information flyer or contact DIZG by email or phone.

History and Clinical Experience

HUMAN SKIN IS COMPOSED OF MULTIPLE LAYERS. The outermost layer (epidermis) consists mostly of epidermal cells (keratinocytes). These keratinocytes significantly contribute to skin renewal and wound closure. The treatment of extensive wounds, such as severe burns without a sufficient remaining number of undamaged epidermal cells for wound closure, as well as the treatment of smaller yet problematic wounds (e.g. chronic wounds), where the natural process of wound healing is impaired, present a large challenge to the field of medicine.

Transplantation

DEPENDING ON THE CELL VOLUME AND CELL SURFACE REQUIRED, epidermal cell cultures can take from 10 days up to 3 weeks time to be available for transplantation. The attending physician carefully removes the epidermal grafts from the transport container and drizzles them directly onto the wound (in the case of an epidermal cell suspension transplant), or applies them in a patch form to the wound area (in the case of an epidermal membrane transplant).

Epidermal Cell Culture

THE EPIDERMAL GRAFTS, CULTURED IN TEST TUBES (A PROCESS ALSO KNOWN AS "IN VITRO"), consist of autologous epidermal cells – the keratinocytes. These grafts may be applied as epidermal membrane or epidermal cell suspension, depending on the type of wound (size, location, shape/form) and the attending physicianʼs assessment.